Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD(+) Synthesis During Inflammation and Infection

Quinolinate (Quin) is a classic example of a biochemical double-edged sword, acting as both essential metabolite and potent neurotoxin. Quin is an important metabolite in the kynurenine pathway of tryptophan catabolism leading to the de novo synthesis of nicotinamide adenine dinucleotide (NAD(+)). A...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Moffett, John R., Arun, Peethambaran, Puthillathu, Narayanan, Vengilote, Ranjini, Ives, John A., Badawy, Abdulla A-B, Namboodiri, Aryan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047773/
https://ncbi.nlm.nih.gov/pubmed/32153556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00031
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