NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

<p>Abstract</p> <p>Background</p> <p>Metabotropic glutamate receptors (mGluRs) have been identified as significant analgesic targets. Systemic treatments with inhibitors of the enzymes that inactivate the peptide transmitter N-acetylaspartylglutamate (NAAG), an mGluR3 a...

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Detalhes bibliográficos
Main Authors: Yamada Toshihiko, Zuo Daiying, Yamamoto Tatsuo, Olszewski Rafal T, Bzdega Tomasz, Moffett John R, Neale Joseph H
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publishing 2012-09-01
Colecção:Molecular Pain
Assuntos:
Analgesia
NAAG
PAG
RVM
mGluR3
LY341495
Inflammatory pain
Microdialysis
Acesso em linha:http://www.molecularpain.com/content/8/1/67
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