NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

BACKGROUND: Metabotropic glutamate receptors (mGluRs) have been identified as significant analgesic targets. Systemic treatments with inhibitors of the enzymes that inactivate the peptide transmitter N-acetylaspartylglutamate (NAAG), an mGluR3 agonist, have an analgesia-like effect in rat models of...

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Detalhes bibliográficos
Main Authors: Yamada, Toshihiko, Zuo, Daiying, Yamamoto, Tatsuo, Olszewski, Rafal T, Bzdega, Tomasz, Moffett, John R, Neale, Joseph H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539905/
https://ncbi.nlm.nih.gov/pubmed/22971334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-67
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