Intranasal Delivery of Obidoxime to the Brain Prevents Mortality and CNS Damage from Organophosphate Poisoning

Intranasal delivery is an emerging method for bypassing the blood brain barrier (BBB) and targeting therapeutics to the CNS. Oximes are used to counteract the effects of organophosphate poisoning, but they do not readily cross the BBB. Therefore, they cannot effectively counteract the central neurop...

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Detalhes bibliográficos
Publicado no:Neurotoxicology
Main Authors: Krishnan, Jishnu K.S., Arun, Peethambaran, Appu, Abhilash P., Vijayakumar, Nivetha, Figueiredo, Taíza H., Braga, Maria F. M., Baskota, Sudikshya, Olsen, Cara H., Farkas, Natalia, Dagata, John, Frey, William H., Moffett, John R., Namboodiri, Aryan M. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808345/
https://ncbi.nlm.nih.gov/pubmed/26751814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2015.12.020
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