Effect of Administration Method, Animal Weight and Age on the Intranasal Delivery of Drugs to the Brain

BACKGROUND: The intranasal route of administration has proven to be an effective method for bypassing the blood brain barrier and avoiding first pass hepatic metabolism when targeting drugs to the brain. Most small molecules gain rapid access to CNS parenchyma when administered intranasally. However...

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Detalhes bibliográficos
Publicado no:J Neurosci Methods
Main Authors: Krishnan, Jishnu K.S., Arun, Peethambaran, Chembukave, Bhadra, Appu, Abhilash P., Vijayakumar, Nivetha, Moffett, John R., Puthillathu, Narayanan, Namboodiri, Aryan M. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517078/
https://ncbi.nlm.nih.gov/pubmed/28499841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneumeth.2017.05.012
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