Intranasal Delivery of Obidoxime to the Brain Prevents Mortality and CNS Damage from Organophosphate Poisoning

Intranasal delivery is an emerging method for bypassing the blood brain barrier (BBB) and targeting therapeutics to the CNS. Oximes are used to counteract the effects of organophosphate poisoning, but they do not readily cross the BBB. Therefore, they cannot effectively counteract the central neurop...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Neurotoxicology
Autori principali: Krishnan, Jishnu K.S., Arun, Peethambaran, Appu, Abhilash P., Vijayakumar, Nivetha, Figueiredo, Taíza H., Braga, Maria F. M., Baskota, Sudikshya, Olsen, Cara H., Farkas, Natalia, Dagata, John, Frey, William H., Moffett, John R., Namboodiri, Aryan M. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808345/
https://ncbi.nlm.nih.gov/pubmed/26751814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2015.12.020
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi