Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease

Genetic mutations that severely diminish the activity of aspartoacylase (ASPA) result in the fatal brain dysmyelinating disorder, Canavan disease. There is no effective treatment. ASPA produces free acetate from the concentrated brain metabolite, N-acetylaspartate (NAA). Because acetyl coenzyme A is...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Arun, Peethambaran, Madhavarao, Chikkathur N., Moffett, John R., Hamilton, Kristen, Grunberg, Neil E., Ariyannur, Prasanth S., Gahl, William A., Anikster, Yair, Mog, Steven, Hallows, William C., Denu, John M., Namboodiri, Aryan M. A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer Netherlands 2010
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877317/
https://ncbi.nlm.nih.gov/pubmed/20464498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-010-9100-z
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