The Contribution of Experimental in vivo Models to Understanding the Mechanisms of Adaptation to Mechanical Loading in Bone

Por Meakin, Lee B., Price, Joanna S., Lanyon, Lance E.
Publicado em 2014

Age-Related Impairment of Bones' Adaptive Response to Loading in Mice Is Associated With Sex-Related Deficiencies in Osteoblasts but No Change in Osteocytes†

Por Meakin, Lee B, Galea, Gabriel L, Sugiyama, Toshihiro, Lanyon, Lance E, Price, Joanna S
Publicado no J Bone Miner Res (2014)

Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice

Por Meakin, Lee B., Udeh, Chinedu, Galea, Gabriel L., Lanyon, Lance E., Price, Joanna S.
Publicado no Bone (2015)

Bones' Adaptive Response to Mechanical Loading Is Essentially Linear Between the Low Strains Associated With Disuse and the High Strains Associated With the Lamellar/Woven Bone Tra...

Por Sugiyama, Toshihiro, Meakin, Lee B, Browne, William J, Galea, Gabriel L, Price, Joanna S, Lanyon, Lance E
Publicado em 2012

Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight

Por Meakin, Lee B., Sugiyama, Toshihiro, Galea, Gabriel L., Browne, William J., Lanyon, Lance E., Price, Joanna S.
Publicado em 2013

Quantification of Alterations in Cortical Bone Geometry Using Site Specificity Software in Mouse models of Aging and the Responses to Ovariectomy and Altered Loading

Por Galea, Gabriel L., Hannuna, Sion, Meakin, Lee B., Delisser, Peter J., Lanyon, Lance E., Price, Joanna S.
Publicado no Front Endocrinol (Lausanne) (2015)

Colored Indicator Undergloves Increase the Detection of Glove Perforations by Surgeons During Small Animal Orthopedic Surgery: A Randomized Controlled Trial

Por Meakin, Lee B., Gilman, Oliver P., Parsons, Kevin J., Burton, Neil J., Langley‐Hobbs, Sorrel J.
Publicado no Vet Surg (2016)

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

Por Galea, Gabriel L., Sunters, Andrew, Meakin, Lee B., Zaman, Gul, Sugiyama, Toshihiro, Lanyon, Lance E., Price, Joanna S.
Publicado em 2011

Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone

Por Todd, Henry, Galea, Gabriel L., Meakin, Lee B., Delisser, Peter J., Lanyon, Lance E., Windahl, Sara H., Price, Joanna S.
Publicado no PLoS One (2015)

Electrosurgery reduces blood loss and immediate postoperative inflammation compared to cold instruments for midline celiotomy in dogs: A randomized controlled trial

Por Meakin, Lee B., Murrell, Jo C., Doran, Ivan C. P., Knowles, Toby G., Tivers, Michael S., Chanoit, Guillaume P. A.
Publicado no Vet Surg (2017)

Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle

Por Galea, Gabriel L., Meakin, Lee B., Harris, Marie A., Delisser, Peter J., Lanyon, Lance E., Harris, Stephen E., Price, Joanna S.
Publicado no Gene (2017)

Protein Kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity

Por Galea, Gabriel L., Meakin, Lee B., Williams, Christopher M., Hulin-Curtis, Sarah L., Lanyon, Lance E., Poole, Alastair W., Price, Joanna S.
Publicado em 2014

Parathyroid hormone's enhancement of bones' osteogenic response to loading is affected by ageing in a dose- and time-dependent manner

Por Meakin, Lee B, Todd, Henry, Delisser, Peter J, Galea, Gabriel L, Moustafa, Alaa, Lanyon, Lance E, Windahl, Sara H, Price, Joanna S
Publicado no Bone (2017)

Spinal Deformity in Aged Zebrafish Is Accompanied by Degenerative Changes to Their Vertebrae that Resemble Osteoarthritis

Por Hayes, Anthony J., Reynolds, Scott, Nowell, Mari A., Meakin, Lee B., Habicher, Judith, Ledin, Johan, Bashford, Andrew, Caterson, Bruce, Hammond, Chrissy L.
Publicado em 2013

Deletion of P58(IPK), the Cellular Inhibitor of the Protein Kinases PKR and PERK, Causes Bone Changes and Joint Degeneration in Mice

Por Gilbert, Sophie J., Meakin, Lee B., Bonnet, Cleo S., Nowell, Mari A., Ladiges, Warren C., Morton, John, Duance, Victor C., Mason, Deborah J.
Publicado em 2014

Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice

Por Sugiyama, Toshihiro, Meakin, Lee B., Galea, Gabriel L., Jackson, Brendan F., Lanyon, Lance E., Ebetino, Frank H., Russell, R. Graham G., Price, Joanna S.
Publicado em 2011

Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost Is Mediate...

Por Galea, Gabriel L., Meakin, Lee B., Sugiyama, Toshihiro, Zebda, Noureddine, Sunters, Andrew, Taipaleenmaki, Hanna, Stein, Gary S., van Wijnen, Andre J., Lanyon, Lance E., Price, Joanna S.
Publicado em 2013

Planar Cell Polarity Aligns Osteoblast Division in Response to Substrate Strain

Por Galea, Gabriel L, Meakin, Lee B, Savery, Dawn, Taipaleenmaki, Hanna, Delisser, Peter, Stein, Gary S, Copp, Andrew J, van Wijnen, Andre J, Lanyon, Lance E, Price, Joanna S
Publicado no J Bone Miner Res (2015)

Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2

Por Galea, Gabriel L., Paradise, Christopher R., Meakin, Lee B., Camilleri, Emily T., Taipaleenmaki, Hanna, Stein, Gary S., Lanyon, Lance E., Price, Joanna S., van Wijnen, Andre J., Dudakovic, Amel
Publicado no Gene X (2020)

Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2

Por Windahl, Sara H, Saxon, Leanne, Börjesson, Anna E, Lagerquist, Marie K, Frenkel, Baruch, Henning, Petra, Lerner, Ulf H, Galea, Gabriel L, Meakin, Lee B, Engdahl, Cecilia, Sjögren, Klara, Antal, Maria C, Krust, Andrée, Chambon, Pierre, Lanyon, Lance E, Price, Joanna S, Ohlsson, Claes
Publicado em 2013