Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle

In old animals, bone's ability to adapt its mass and architecture to functional load-bearing requirements is diminished, resulting in bone loss characteristic of osteoporosis. Here we investigate transcriptomic changes associated with this impaired adaptive response. Young adult (19-week-old) a...

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Detalhes bibliográficos
Publicado no:Gene
Main Authors: Galea, Gabriel L., Meakin, Lee B., Harris, Marie A., Delisser, Peter J., Lanyon, Lance E., Harris, Stephen E., Price, Joanna S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier/North-Holland 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139832/
https://ncbi.nlm.nih.gov/pubmed/27840164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2016.11.006
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