Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

Sclerostin is a potent inhibitor of bone formation which is down-regulated by mechanical loading. To investigate the mechanisms involved we subjected Saos2 human osteoblastic cells to short periods of dynamic strain and used quantitative reverse transcriptase polymerase chain reaction to compare the...

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Hlavní autoři: Galea, Gabriel L., Sunters, Andrew, Meakin, Lee B., Zaman, Gul, Sugiyama, Toshihiro, Lanyon, Lance E., Price, Joanna S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science B.V 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149668/
https://ncbi.nlm.nih.gov/pubmed/21723865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2011.06.019
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