Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling

The capacity of bones to adjust their mass and architecture to withstand the loads of everyday activity derives from the ability of their resident cells to respond appropriately to the strains engendered. To elucidate the mechanisms of strain responsiveness in bone cells, we investigated in vitro th...

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Detalhes bibliográficos
Main Authors: Sunters, Andrew, Armstrong, Victoria J., Zaman, Gul, Kypta, Robert M., Kawano, Yoshiaki, Lanyon, Lance E., Price, Joanna S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838297/
https://ncbi.nlm.nih.gov/pubmed/20042609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.027086
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