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Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4
Sclerostin is a potent inhibitor of bone formation which is down-regulated by mechanical loading. To investigate the mechanisms involved we subjected Saos2 human osteoblastic cells to short periods of dynamic strain and used quantitative reverse transcriptase polymerase chain reaction to compare the...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier Science B.V
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3149668/ https://ncbi.nlm.nih.gov/pubmed/21723865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2011.06.019 |
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