Dying to Survive—The p53 Paradox

di Lees, Andrea, Sessler, Tamas, McDade, Simon
Pubblicato in Cancers (Basel) (2021)

p63 maintains keratinocyte proliferative capacity through regulation of Skp2–p130 levels

di McDade, Simon S., Patel, Daksha, McCance, Dennis J.
Pubblicazione 2011

p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling

di Srivastava, Kirtiman, Pickard, Adam, McDade, Simon, McCance, Dennis J
Pubblicato in Oncotarget (2015)

Tumor suppressor p53: from engaging DNA to target gene regulation

di Sammons, Morgan A, Nguyen, Thuy-Ai T, McDade, Simon S, Fischer, Martin
Pubblicato in Nucleic Acids Res (2020)

MicroRNA 203 Expression in Keratinocytes Is Dependent on Regulation of p53 Levels by E6

di McKenna, Declan J., McDade, Simon S., Patel, Daksha, McCance, Dennis J.
Pubblicazione 2010

Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

di Riege, Konstantin, Kretzmer, Helene, Sahm, Arne, McDade, Simon S, Hoffmann, Steve, Fischer, Martin
Pubblicato in eLife (2020)

Role of ΔNp63γ in Epithelial to Mesenchymal Transition

di Lindsay, Jaime, McDade, Simon S., Pickard, Adam, McCloskey, Karen D., McCance, Dennis J.
Pubblicazione 2011

SynLeGG: analysis and visualization of multiomics data for discovery of cancer ‘Achilles Heels’ and gene function relationships

di Wappett, Mark, Harris, Adam, Lubbock, Alexander L R, Lobb, Ian, McDade, Simon, Overton, Ian M
Pubblicato in Nucleic Acids Res (2021)

HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures

di Pickard, Adam, McDade, Simon S., McFarland, Marie, McCluggage, W. Glenn, Wheeler, Cosette M., McCance, Dennis J.
Pubblicato in PLoS Pathog (2015)

Evidence for Alteration of EZH2, BMI1, and KDM6A and Epigenetic Reprogramming in Human Papillomavirus Type 16 E6/E7-Expressing Keratinocytes

di Hyland, Paula L., McDade, Simon S., McCloskey, Rachel, Dickson, Glenda J., Arthur, Ken, McCance, Dennis J., Patel, Daksha
Pubblicazione 2011

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis

di Gorski, Julia J., Savage, Kienan I., Mulligan, Jude M., McDade, Simon S., Blayney, Jaine K., Ge, Zhaoping, Harkin, D. Paul
Pubblicazione 2011

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells

di Cichon, Ann-Christin, Pickard, Adam, McDade, Simon S., Sharpe, Daniel J., Moran, Michael, James, Jacqueline A., McCance, Dennis J.
Pubblicazione 2013

Functional and genetic analysis of the colon cancer network

di Emmert-Streib, Frank, de Matos Simoes, Ricardo, Glazko, Galina, McDade, Simon, Haibe-Kains, Benjamin, Holzinger, Andreas, Dehmer, Matthias, Campbell, Frederick Charles
Pubblicazione 2014

ΔNp63γ/SRC/Slug signalling axis promotes epithelial-to-mesenchymal transition in squamous cancers

di Srivastava, Kirtiman, Pickard, Adam, Craig, Stephanie G, Quinn, Gerard P, Lambe, Shauna M, James, Jacqueline A, McDade, Simon S, McCance, Dennis J.
Pubblicato in Clin Cancer Res (2018)

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML

di Smith, James S., Lappin, Katrina M., Craig, Stephanie G., Liberante, Fabio G., Crean, Clare M., McDade, Simon S., Thompson, Alexander, Mills, Ken I., Savage, Kienan I.
Pubblicato in J Transl Med (2020)

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

di McDade, Simon S., Patel, Daksha, Moran, Michael, Campbell, James, Fenwick, Kerry, Kozarewa, Iwanka, Orr, Nicholas J., Lord, Christopher J., Ashworth, Alan A., McCance, Dennis J.
Pubblicazione 2014

Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer

di Ferris, Jennifer, Espona-Fiedler, Margarita, Hamilton, Claudia, Holohan, Caitriona, Crawford, Nyree, McIntyre, Alex J., Roberts, Jamie Z., Wappett, Mark, McDade, Simon S., Longley, Daniel B., Coyle, Victoria
Pubblicato in Cell Death Discov (2020)

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists

di McCann, Christopher, Crawford, Nyree, Majkut, Joanna, Holohan, Caitriona, Armstrong, Chris W. D., Maxwell, Pamela J., Ong, Chee Wee, LaBonte, Melissa J., McDade, Simon S., Waugh, David J., Longley, Daniel B.
Pubblicato in Cell Death Dis (2018)

Ruthenium Drug BOLD-100 Regulates BRAFMT Colorectal Cancer Cell Apoptosis through AhR/ROS/ATR Signaling Axis Modulation

di Griffin, Daryl, Carson, Robbie, Moss, Debbie, Sessler, Tamas, Lavin, Deborah, Tiwari, Vijay K., Karelia, Shivaali, Kennedy, Richard, Savage, Kienan I., McDade, Simon, Carie, Adam, Pankovich, Jim, Bazett, Mark, Van Schaeybroeck, Sandra
Pubblicato in Mol Cancer Res (2024)

Transcription factor activities enhance markers of drug sensitivity in cancer

di Garcia-Alonso, Luz, Iorio, Francesco, Matchan, Angela, Fonseca, Nuno, Jaaks, Patricia, Peat, Gareth, Pignatelli, Miguel, Falcone, Fiammetta, Benes, Cyril H., Dunham, Ian, Bignell, Graham, McDade, Simon S., Garnett, Mathew J., Saez-Rodriguez, Julio
Pubblicato in Cancer Res (2018)