Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

In response to genotoxic stress the TP53 tumour suppressor activates target gene expression to induce cell cycle arrest or apoptosis depending on the extent of DNA damage. These canonical activities can be repressed by TP63 in normal stratifying epithelia to maintain proliferative capacity or drive...

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Detalhes bibliográficos
Main Authors: McDade, Simon S., Patel, Daksha, Moran, Michael, Campbell, James, Fenwick, Kerry, Kozarewa, Iwanka, Orr, Nicholas J., Lord, Christopher J., Ashworth, Alan A., McCance, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041465/
https://ncbi.nlm.nih.gov/pubmed/24823795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku299
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