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p63 maintains keratinocyte proliferative capacity through regulation of Skp2–p130 levels

p63 is a master regulator of proliferation and differentiation in stratifying epithelia, and its expression is frequently altered in carcinogenesis. However, its role in maintaining proliferative capacity remains unclear. Here, we demonstrate that hypoproliferation and loss of differentiation in org...

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Detalhes bibliográficos
Main Authors: McDade, Simon S., Patel, Daksha, McCance, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085435/
https://ncbi.nlm.nih.gov/pubmed/21511729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.084723
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