Nutrient transporters: the Achilles' heel of anabolism

Por McCracken, Alison N., Edinger, Aimee L.
Publicado em 2013

Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14

Por McCracken, Alison N., Edinger, Aimee L.
Publicado no Biochem J (2015)

Design, Synthesis, and Antileukemic Activity of Stereochemically Defined Constrained Analogues of FTY720 (Gilenya)

Por Fransson, Rebecca, McCracken, Alison N., Chen, Bin, McMonigle, Ryan J., Edinger, Aimee L., Hanessian, Stephen
Publicado em 2013

In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways

Por Garsi, Jean-Baptiste, Sernissi, Lorenzo, Vece, Vito, Hanessian, Stephen, McCracken, Alison N., Simitian, Grigor, Edinger, Aimee L.
Publicado no Eur J Med Chem (2018)

Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs

Por Kubiniok, Peter, Finicle, Brendan T., Piffaretti, Fanny, McCracken, Alison N., Perryman, Michael, Hanessian, Stephen, Edinger, Aimee L., Thibault, Pierre
Publicado no Mol Cell Proteomics (2019)

Loss of TSC2 confers resistance to ceramide and nutrient deprivation

Por Guenther, Garret G., Liu, Gang, Ramirez, Manuel U., McMonigle, Ryan J., Kim, Seong M., McCracken, Alison N., Joo, Yoosun, Ushach, Irina, Nguyen, Natalie L., Edinger, Aimee L.
Publicado em 2013

Azacyclic FTY720 Analogues that Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill...

Por Chen, Bin, Roy, Saurabh G., McMonigle, Ryan J., Keebaugh, Andrew, McCracken, Alison N., Selwan, Elizabeth, Fransson, Rebecca, Fallegger, Daniel, Huwiler, Andrea, Kleinman, Michael T., Edinger, Aimee L., Hanessian, Stephen
Publicado no ACS Chem Biol (2015)

Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6

Por Finicle, Brendan T., Ramirez, Manuel U., Liu, Gang, Selwan, Elizabeth M., McCracken, Alison N., Yu, Jingwen, Joo, Yoosun, Nguyen, Jannett, Ou, Kevin, Roy, Saurabh Ghosh, Mendoza, Victor D., Corrales, Dania Virginia, Edinger, Aimee L.
Publicado no J Cell Sci (2018)

Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation

Por McCracken, Alison N., McMonigle, Ryan J., Tessier, Jérémie, Fransson, Rebecca, Perryman, Michael S., Chen, Bin, Keebaugh, Andrew, Selwan, Elizabeth, Barr, Sarah A., Kim, Seong M., Roy, Saurabh G., Liu, Gang, Fallegger, Daniel, Sernissi, Lorenzo, Brandt, Cordelia, Moitessier, Nicolas, Snider, Ashley J., Clare, Simon, Müschen, Markus, Huwiler, Andrea, Kleinman, Michael T., Hanessian, Stephen, Edinger, Aimee L.
Publicado no Leukemia (2016)

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

Por Kim, Seong M., Roy, Saurabh G., Chen, Bin, Nguyen, Tiffany M., McMonigle, Ryan J., McCracken, Alison N., Zhang, Yanling, Kofuji, Satoshi, Hou, Jue, Selwan, Elizabeth, Finicle, Brendan T., Nguyen, Tricia T., Ravi, Archna, Ramirez, Manuel U., Wiher, Tim, Guenther, Garret G., Kono, Mari, Sasaki, Atsuo T., Weisman, Lois S., Potma, Eric O., Tromberg, Bruce J., Edwards, Robert A., Hanessian, Stephen, Edinger, Aimee L.
Publicado no J Clin Invest (2016)