Metabolic instability of cyanothiazolidine-based prolyl oligopeptidase inhibitors: a structural assignment challenge and potential medicinal chemistry implications

Por Schiavini, Paolo, Pottel, Joshua, Moitessier, Nicolas, Auclair, Karine
Publicado no ChemMedChem (2015)

Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry

Por Di Trani, Justin M., De Cesco, Stephane, O’Leary, Rebecca, Plescia, Jessica, do Nascimento, Claudia Jorge, Moitessier, Nicolas, Mittermaier, Anthony K.
Publicado no Nat Commun (2018)

Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation

Por McCracken, Alison N., McMonigle, Ryan J., Tessier, Jérémie, Fransson, Rebecca, Perryman, Michael S., Chen, Bin, Keebaugh, Andrew, Selwan, Elizabeth, Barr, Sarah A., Kim, Seong M., Roy, Saurabh G., Liu, Gang, Fallegger, Daniel, Sernissi, Lorenzo, Brandt, Cordelia, Moitessier, Nicolas, Snider, Ashley J., Clare, Simon, Müschen, Markus, Huwiler, Andrea, Kleinman, Michael T., Hanessian, Stephen, Edinger, Aimee L.
Publicado no Leukemia (2016)