Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6

Endogenous sphingolipids (ceramide) and related synthetic molecules (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins. Here, we report that these sphingolipids disrupt endocytic recycling by inactivating the small GTPase ARF...

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Publicat a:J Cell Sci
Autors principals: Finicle, Brendan T., Ramirez, Manuel U., Liu, Gang, Selwan, Elizabeth M., McCracken, Alison N., Yu, Jingwen, Joo, Yoosun, Nguyen, Jannett, Ou, Kevin, Roy, Saurabh Ghosh, Mendoza, Victor D., Corrales, Dania Virginia, Edinger, Aimee L.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031383/
https://ncbi.nlm.nih.gov/pubmed/29848659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.213314
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