Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6

Endogenous sphingolipids (ceramide) and related synthetic molecules (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins. Here, we report that these sphingolipids disrupt endocytic recycling by inactivating the small GTPase ARF...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Finicle, Brendan T., Ramirez, Manuel U., Liu, Gang, Selwan, Elizabeth M., McCracken, Alison N., Yu, Jingwen, Joo, Yoosun, Nguyen, Jannett, Ou, Kevin, Roy, Saurabh Ghosh, Mendoza, Victor D., Corrales, Dania Virginia, Edinger, Aimee L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031383/
https://ncbi.nlm.nih.gov/pubmed/29848659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.213314
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