Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6

Endogenous sphingolipids (ceramide) and related synthetic molecules (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins. Here, we report that these sphingolipids disrupt endocytic recycling by inactivating the small GTPase ARF...

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Detalles Bibliográficos
Publicado en:J Cell Sci
Main Authors: Finicle, Brendan T., Ramirez, Manuel U., Liu, Gang, Selwan, Elizabeth M., McCracken, Alison N., Yu, Jingwen, Joo, Yoosun, Nguyen, Jannett, Ou, Kevin, Roy, Saurabh Ghosh, Mendoza, Victor D., Corrales, Dania Virginia, Edinger, Aimee L.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031383/
https://ncbi.nlm.nih.gov/pubmed/29848659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.213314
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