Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6

Endogenous sphingolipids (ceramide) and related synthetic molecules (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins. Here, we report that these sphingolipids disrupt endocytic recycling by inactivating the small GTPase ARF...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Cell Sci
Hlavní autoři: Finicle, Brendan T., Ramirez, Manuel U., Liu, Gang, Selwan, Elizabeth M., McCracken, Alison N., Yu, Jingwen, Joo, Yoosun, Nguyen, Jannett, Ou, Kevin, Roy, Saurabh Ghosh, Mendoza, Victor D., Corrales, Dania Virginia, Edinger, Aimee L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031383/
https://ncbi.nlm.nih.gov/pubmed/29848659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.213314
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky