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Starving PTEN-deficient prostate cancer cells thrive under nutrient stress by scavenging corpses for their supper

Our recent work demonstrates that inactivating mutations in phosphatase and tensin homolog (PTEN) are sufficient to drive macropinocytosis in the context of AMP-activated protein kinase (AMPK) activation. Given that blocking macropinocytosis limits PTEN-deficient prostate tumor growth, AMPK or phosp...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Jayashankar, Vaishali, Finicle, Brendan T., Edinger, Aimee L.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149707/
https://ncbi.nlm.nih.gov/pubmed/30250923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1472060
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