PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells

We report that PTEN-deficient prostate cancer cells use macropinocytosis to survive and proliferate under nutrient stress. PTEN loss increased macropinocytosis only in the context of AMPK activation revealing a general requirement for AMPK in macropinocytosis and a novel mechanism by which AMPK prom...

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Bibliografiska uppgifter
I publikationen:Cancer Discov
Huvudupphovsmän: Kim, Seong M., Nguyen, Tricia T., Ravi, Archna, Kubiniok, Peter, Finicle, Brendan T., Jayashankar, Vaishali, Malacrida, Leonel, Hou, Jue, Robertson, Jane, Gao, Dong, Chernoff, Jonathan, Digman, Michelle A., Potma, Eric O., Tromberg, Bruce J., Thibault, Pierre, Edinger, Aimee L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030497/
https://ncbi.nlm.nih.gov/pubmed/29572236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-1215
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