Development of Novel Therapeutics Targeting the Urokinase Plasminogen Activator Receptor (uPAR) and Their Translation Toward the Clinic

Por Mazar, Andrew P., Ahn, Richard W., O'Halloran, Thomas V.
Publicado em 2011

Regulation of intrapleural fibrinolysis by urokinase-α-macroglobulin complexes in tetracycline-induced pleural injury in rabbits

Por Komissarov, Andrey A., Mazar, Andrew P., Koenig, Kathy, Kurdowska, Anna K., Idell, Steven
Publicado em 2009

The Many Spaces of uPAR: Delivery of Theranostic Agents and Nanobins to Multiple Tumor Compartments through a Single Target

Por O'Halloran, Thomas V., Ahn, Richard, Hankins, Patrick, Swindell, Elden, Mazar, Andrew P.
Publicado em 2013

Targeting SOD1 reduces experimental non–small-cell lung cancer

Por Glasauer, Andrea, Sena, Laura A., Diebold, Lauren P., Mazar, Andrew P., Chandel, Navdeep S.
Publicado em 2013

The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma

Por LEE, KRISTY, HART, MATTHEW R., BRIEHL, MARGARET M., MAZAR, ANDREW P., TOME, MARGARET E.
Publicado em 2014

Regulation of Urokinase Receptor Expression by p53: Novel Role in Stabilization of uPAR mRNA

Por Shetty, Sreerama, Velusamy, Thirunavukkarasu, Idell, Steven, Shetty, Praveenkumar, Mazar, Andrew P., Bhandary, Yashodhar P., Shetty, Rashmi S.
Publicado em 2007

α5β1 Integrin Signaling Mediates Oxidized LDL-Induced Inflammation and Early Atherosclerosis

Por Yurdagul, Arif, Green, Jonette, Albert, Patrick, McInnis, Marshall C., Mazar, Andrew P., Orr, A. Wayne
Publicado em 2014

GSK-3β inhibitor, 9-ING-41, reduces cell viability and halts proliferation of B-cell lymphoma cell lines as a single agent and in combination with novel agents

Por Karmali, Reem, Chukkapalli, Vineela, Gordon, Leo I., Borgia, Jeffrey A., Ugolkov, Andrey, Mazar, Andrew P., Giles, Francis J.
Publicado no Oncotarget (2017)

The Urokinase Receptor Supports Tumorigenesis of Human Malignant Pleural Mesothelioma Cells

Por Tucker, Torry A., Dean, Candice, Komissarov, Andrey A., Koenig, Kathy, Mazar, Andrew P., Pendurthi, Usha, Allen, Timothy, Idell, Steven
Publicado em 2010

Virtual High-Throughput Screening To Identify Novel Activin Antagonists

Por Zhu, Jie, Mishra, Rama K., Schiltz, Gary E., Makanji, Yogeshwar, Scheidt, Karl A., Mazar, Andrew P., Woodruff, Teresa K.
Publicado no J Med Chem (2015)

Melanoma cells block PEDF production in fibroblasts to induce the tumor-promoting phenotype of cancer-associated fibroblasts

Por Nwani, Nkechiyere G, Deguiz, Maria L, Jimenez, Benilde, Vinokour, Elena, Dubrovskyi, Oleksii, Ugolkov, Andrey, Mazar, Andrew P, Volpert, Olga V
Publicado no Cancer Res (2016)

An Anti-Urokinase Plasminogen Activator Receptor Antibody (ATN-658) Blocks Prostate Cancer Invasion, Migration, Growth, and Experimental Skeletal Metastasis In Vitro and In Vivo

Por Rabbani, Shafaat A, Ateeq, Bushra, Arakelian, Ani, Valentino, Maria Luisa, Shaw, David E, Dauffenbach, Lisa M, Kerfoot, Christopher A, Mazar, Andrew P
Publicado em 2010

Copper Chelator ATN-224 Induces Peroxynitrite-Dependent Cell Death in Hematological Malignancies

Por Lee, Kristy, Briehl, Margaret M., Mazar, Andrew P., Batinic-Haberle, Ines, Reboucas, Julio S., Glinsmann-Gibson, Betty, Rimsza, Lisa M., Tome, Margaret E.
Publicado em 2013

Targeting the Urokinase Plasminogen Activator Receptor With a Monoclonal Antibody Impairs the Growth of Human Colorectal Cancer in the Liver

Por Van Buren, George, Gray, Michael J., Dallas, Nikolaos A., Xia, Ling, Lim, Sherry J., Fan, Fan, Mazar, Andrew P., Ellis, Lee M.
Publicado no Cancer (2009)

The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin

Por Zhang, Jing-Chuan, Doñate, Fernando, Qi, Xiaoping, Ziats, Nicholas P., Juarez, Jose C., Mazar, Andrew P., Pang, Yuan-Ping, McCrae, Keith R.
Publicado em 2002

Superoxide dismutase 1 (SOD1) is essential for H(2)O(2)-mediated oxidation and inactivation of phosphatases in growth factor signaling

Por Juarez, Jose C., Manuia, Mari, Burnett, Mark E., Betancourt, Oscar, Boivin, Benoit, Shaw, David E., Tonks, Nicholas K., Mazar, Andrew P., Doñate, Fernando
Publicado em 2008

Discovery of the Antitumor Effects of a Porphyrazine Diol (Pz 285) in MDA-MB-231 Breast Tumor Xenograft Models in Mice

Por Kandela, Irawati K., McAuliffe, Katherine J., Cochran, Lauren E., Barrett, Anthony G. M., Hoffman, Brian M., Mazar, Andrew P., Trivedi, Evan R.
Publicado no ACS Med Chem Lett (2017)

Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

Por Huai, Qing, Zhou, Aiwu, Lin, Lin, Mazar, Andrew P, Parry, Graham C, Callahan, Jennifer, Shaw, David E, Furie, Bruce, Furie, Barbara C, Huang, Mingdong
Publicado em 2008

Targeting the Urokinase Plasminogen Activator Receptor Inhibits Ovarian Cancer Metastasis

Por Kenny, Hilary A., Leonhardt, Payton, Ladanyi, Andras, Yamada, S. Diane, Montag, Anthony, Im, Hae Kyung, Jagadeeswaran, Sujatha, Shaw, David E., Mazar, Andrew P., Lengyel, Ernst
Publicado em 2010

Patient-Derived Tumor Xenografts Are Susceptible to Formation of Human Lymphocytic Tumors()

Por Bondarenko, Gennadiy, Ugolkov, Andrey, Rohan, Stephen, Kulesza, Piotr, Dubrovskyi, Oleksii, Gursel, Demirkan, Mathews, Jeremy, O’Halloran, Thomas V., Wei, Jian J., Mazar, Andrew P.
Publicado no Neoplasia (2015)