Superoxide dismutase 1 (SOD1) is essential for H(2)O(2)-mediated oxidation and inactivation of phosphatases in growth factor signaling

Superoxide dismutase 1 (SOD1) is an abundant copper/zinc enzyme found in the cytoplasm that converts superoxide into hydrogen peroxide and molecular oxygen. Tetrathiomolybdate (ATN-224) has been recently identified as an inhibitor of SOD1 that attenuates FGF-2- and VEGF-mediated phosphorylation of E...

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Detalhes bibliográficos
Main Authors: Juarez, Jose C., Manuia, Mari, Burnett, Mark E., Betancourt, Oscar, Boivin, Benoit, Shaw, David E., Tonks, Nicholas K., Mazar, Andrew P., Doñate, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438219/
https://ncbi.nlm.nih.gov/pubmed/18480265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709451105
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