Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)

Tetrathiomolybdate (choline salt; ATN-224), a specific, high-affinity copper binder, is currently being evaluated in several phase II cancer trials. ATN-224 inhibits CuZn superoxide dismutase 1 (SOD1) leading to antiangiogenic and antitumour effects. The pharmacodynamics of tetrathiomolybdate has be...

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Detalhes bibliográficos
Main Authors: Doñate, F, Juarez, J C, Burnett, M E, Manuia, M M, Guan, X, Shaw, D E, Smith, E L P, Timucin, C, Braunstein, M J, Batuman, O A, Mazar, A P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2259182/
https://ncbi.nlm.nih.gov/pubmed/18253124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604226
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