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Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the rec...

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Detalhes bibliográficos
Main Authors: Huai, Qing, Zhou, Aiwu, Lin, Lin, Mazar, Andrew P, Parry, Graham C, Callahan, Jennifer, Shaw, David E, Furie, Bruce, Furie, Barbara C, Huang, Mingdong
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443823/
https://ncbi.nlm.nih.gov/pubmed/18376415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1404
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