The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa

Por Maddukuri, Leena, Ketkar, Amit, Eddy, Sarah, Zafar, Maroof K., Eoff, Robert L.
Publicado no Nucleic Acids Res (2014)

SEMISYNTHESIS OF 6-CHLOROPURINE-2′-DEOXYRIBOSIDE 5′-DIMETHOXYTRITYL 3′-(2-CYANOETHYL-N,N-DIISOPROPYLAMINO)PHOSPHORAMIDITE AND ITS USE IN THE SYNTHESIS OF FLUORESCENTLY LABELED OLIG...

Por Uddin, Md. Jashim, Schulte, Michael I., Maddukuri, Leena, Harp, Joel, Marnett, Lawrence J.
Publicado em 2010

Human translesion polymerase kappa exhibits enhanced activity and reduced fidelity two nucleotides from G-quadruplex DNA

Por Eddy, Sarah, Tillman, Magdalena, Maddukuri, Leena, Ketkar, Amit, Zafar, Maroof K., Eoff, Robert L.
Publicado no Biochemistry (2016)

Enhancement of Human DNA Polymerase η Activity and Fidelity Is Dependent Upon a Bipartite Interaction with the Werner Syndrome Protein

Por Maddukuri, Leena, Ketkar, Amit, Eddy, Sarah, Zafar, Maroof K., Griffin, Wezley C., Eoff, Robert L.
Publicado em 2012

Human Rev1 polymerase disrupts G-quadruplex DNA

Por Eddy, Sarah, Ketkar, Amit, Zafar, Maroof K., Maddukuri, Leena, Choi, Jeong-Yun, Eoff, Robert L.
Publicado em 2014

In Vitro Bypass of the Major Malondialdehyde- and Base Propenal-Derived DNA Adduct by Human Y-family DNA Polymerases κ, ι, and Rev1

Por Maddukuri, Leena, Eoff, Robert L., Choi, Jeong-Yun, Rizzo, Carmelo J., Guengerich, F. Peter, Marnett, Lawrence J.
Publicado em 2010

Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA

Por Eddy, Sarah, Maddukuri, Leena, Ketkar, Amit, Zafar, Maroof K., Henninger, Erin E., Pursell, Zachary F., Eoff, Robert L.
Publicado no Biochemistry (2015)

Replication, Repair and Translesion Polymerase Bypass of N(6)-Oxopropenyl-2′-deoxyadenosine

Por Maddukuri, Leena, Shuck, Sarah C., Eoff, Robert L., Zhao, Linlin, Rizzo, Carmelo J., Guengerich, F. Peter, Marnett, Lawrence J.
Publicado em 2013

N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases

Por Coggins, Grace E., Maddukuri, Leena, Penthala, Narsima R., Hartman, Jessica H., Eddy, Sarah, Ketkar, Amit, Crooks, Peter A., Eoff, Robert L.
Publicado em 2013

Translesion Synthesis across 1,N(6)-(2-Hydroxy-3-hydroxymethylpropan-1,3-diyl)-2′-deoxyadenosine (1,N(6)-γ-HMHP-dA) Adducts by Human and Archebacterial DNA Polymerases

Por Kotapati, Srikanth, Maddukuri, Leena, Wickramaratne, Susith, Seneviratne, Uthpala, Goggin, Melissa, Pence, Matthew G., Villalta, Peter, Guengerich, F. Peter, Marnett, Lawrence, Tretyakova, Natalia
Publicado em 2012

The leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity

Por Ketkar, Amit, Zafar, Maroof K., Maddukuri, Leena, Yamanaka, Kinrin, Banerjee, Surajit, Egli, Martin, Choi, Jeong-Yun, Lloyd, R. Stephen, Eoff, Robert L.
Publicado em 2013

Selective Modulation of DNA Polymerase Activity by Fixed Conformation Nucleoside Analogues

Por Eoff, Robert L., McGrath, Colleen E., Maddukuri, Leena, Salamanca-Pinzón, S. Giovanna, Marquez, Victor E., Marnett, Lawrence J., Guengerich, F. Peter, Egli, Martin
Publicado em 2010

Kynurenine signaling increases DNA polymerase kappa expression and promotes genomic instability in glioblastoma cells

Por Bostian, April C.L., Maddukuri, Leena, Reed, Megan R., Savenka, Tatsiana, Hartman, Jessica H., Davis, Lauren, Pouncey, Dakota L., Miller, Grover P., Eoff, Robert L.
Publicado no Chem Res Toxicol (2015)

Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal

Por Maddukuri, Leena, Speina, Elżbieta, Christiansen, Mette, Dudzińska, Dominika, Zaim, Jolanta, Obtułowicz, Tomasz, Kabaczyk, Sylwia, Komisarski, Marek, Bukowy, Zuzanna, Szczegielniak, Jadwiga, Wójcik, Andrzej, Kuśmierek, Jaroslaw T., Stevnsner, Tinna, Bohr, Vilhelm A., Tudek, Barbara
Publicado no Mutat Res (2009)

Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress

Por Byrd, Alicia K., Zybailov, Boris L., Maddukuri, Leena, Gao, Jun, Marecki, John C., Jaiswal, Mihir, Bell, Matthew R., Griffin, Wezley C., Reed, Megan R., Chib, Shubeena, Mackintosh, Samuel G., MacNicol, Angus M., Baldini, Giulia, Eoff, Robert L., Raney, Kevin D.
Publicado no J Biol Chem (2016)