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Enhancement of Human DNA Polymerase η Activity and Fidelity Is Dependent Upon a Bipartite Interaction with the Werner Syndrome Protein

We have investigated the interaction between human DNA polymerase η (hpol η) and the Werner syndrome protein (WRN). Functional assays revealed that the WRN exonuclease and RecQ C-terminal (RQC) domains are necessary for full stimulation of hpol η-catalyzed formation of correct base pairs. We find th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Maddukuri, Leena, Ketkar, Amit, Eddy, Sarah, Zafar, Maroof K., Griffin, Wezley C., Eoff, Robert L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516774/
https://ncbi.nlm.nih.gov/pubmed/23045531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410332
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