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Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA
We have investigated the action of the human DNA polymerase epsilon (hpol ε) and eta (hpol η) catalytic cores on G-quadruplex (G4) DNA substrates derived from the promoter of the c-MYC proto-oncogene. The translesion enzyme hpol η exhibits a 6.2-fold preference for binding to G4 DNA relative to non-...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4682564/ https://ncbi.nlm.nih.gov/pubmed/25903680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00060 |
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