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Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA

We have investigated the action of the human DNA polymerase epsilon (hpol ε) and eta (hpol η) catalytic cores on G-quadruplex (G4) DNA substrates derived from the promoter of the c-MYC proto-oncogene. The translesion enzyme hpol η exhibits a 6.2-fold preference for binding to G4 DNA relative to non-...

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Publicado en:Biochemistry
Autores principales: Eddy, Sarah, Maddukuri, Leena, Ketkar, Amit, Zafar, Maroof K., Henninger, Erin E., Pursell, Zachary F., Eoff, Robert L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682564/
https://ncbi.nlm.nih.gov/pubmed/25903680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00060
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