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The leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity
Specialized DNA polymerases participate in replication stress responses and in DNA repair pathways that function as barriers against cellular senescence and genomic instability. These events can be co-opted by tumor cells as a mechanism to survive chemotherapeutic and ionizing radiation treatments,...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3578163/ https://ncbi.nlm.nih.gov/pubmed/23305233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300392m |
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