Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress

Cells engage numerous signaling pathways in response to oxidative stress that together repair macromolecular damage or direct the cell toward apoptosis. As a result of DNA damage, mitochondrial DNA or nuclear DNA has been shown to enter the cytoplasm where it binds to “DNA sensors,” which in turn in...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Byrd, Alicia K., Zybailov, Boris L., Maddukuri, Leena, Gao, Jun, Marecki, John C., Jaiswal, Mihir, Bell, Matthew R., Griffin, Wezley C., Reed, Megan R., Chib, Shubeena, Mackintosh, Samuel G., MacNicol, Angus M., Baldini, Giulia, Eoff, Robert L., Raney, Kevin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016190/
https://ncbi.nlm.nih.gov/pubmed/27369081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718478
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