Translesion Synthesis across 1,N(6)-(2-Hydroxy-3-hydroxymethylpropan-1,3-diyl)-2′-deoxyadenosine (1,N(6)-γ-HMHP-dA) Adducts by Human and Archebacterial DNA Polymerases

The 1,N(6)-(2-Hydroxy-3-hydroxymethylpropan-1,3-diyl)-2′-deoxyadenosine (1,N(6)-γ-HMHP-dA) adducts are formed upon bifunctional alkylation of adenine nucleobases in DNA by 1,2,3,4-diepoxybutane, the putative ultimate carcinogenic metabolite of 1,3-butadiene. The presence of a substituted 1,N(6)-prop...

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Detalhes bibliográficos
Main Authors: Kotapati, Srikanth, Maddukuri, Leena, Wickramaratne, Susith, Seneviratne, Uthpala, Goggin, Melissa, Pence, Matthew G., Villalta, Peter, Guengerich, F. Peter, Marnett, Lawrence, Tretyakova, Natalia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493922/
https://ncbi.nlm.nih.gov/pubmed/22977231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.396788
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