Polymerase Bypass of N(6)-Deoxyadenosine Adducts Derived from Epoxide Metabolites of 1,3-Butadiene

N (6)-(2-Hydroxy-3-buten-1-yl)-2′-deoxyadenosine (N(6)-HB-dA I) and N(6),N(6)-(2,3-dihydroxybutan-1,4-diyl)-2′-deoxyadenosine (N(6),N(6)-DHB-dA) are exocyclic DNA adducts formed upon alkylation of the N(6) position of adenine in DNA by epoxide metabolites of 1,3-butadiene (BD), a common industrial a...

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Détails bibliographiques
Publié dans:Chem Res Toxicol
Auteurs principaux: Kotapati, Srikanth, Wickramaratne, Susith, Esades, Amanda, Boldry, Emily J., Dorr, Danae Quirk, Pence, Matthew G., Guengerich, F. Peter, Tretyakova, Natalia Y.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704788/
https://ncbi.nlm.nih.gov/pubmed/26098310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00166
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