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In Vitro Bypass of the Major Malondialdehyde- and Base Propenal-Derived DNA Adduct by Human Y-family DNA Polymerases κ, ι, and Rev1

[Image: see text] 3-(2′-Deoxy-β-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one (M(1)dG) is the major adduct derived from the reaction of DNA with the lipid peroxidation product malondialdehyde and the DNA peroxidation product base propenal. M(1)dG is mutagenic in Escherichia coli and mamm...

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Detalhes bibliográficos
Main Authors: Maddukuri, Leena, Eoff, Robert L., Choi, Jeong-Yun, Rizzo, Carmelo J., Guengerich, F. Peter, Marnett, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943251/
https://ncbi.nlm.nih.gov/pubmed/20726503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1009024
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