Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes

par Giagounidis, Aristoteles, Mufti, Ghulam J., Fenaux, Pierre, Germing, Ulrich, List, Alan, MacBeth, Kyle J.
Publié 2013

Azacitidine and decitabine have different mechanisms of action in non-small cell lung cancer cell lines

par Nguyen, Aaron N, Hollenbach, Paul W, Richard, Normand, Luna-Moran, Antonio, Brady, Helen, Heise, Carla, MacBeth, Kyle J
Publié dans Lung Cancer (Auckl) (2010)

Pharmacokinetics and Pharmacodynamics with Extended Dosing of CC-486 in Patients with Hematologic Malignancies

par Laille, Eric, Shi, Tao, Garcia-Manero, Guillermo, Cogle, Christopher R., Gore, Steven D., Hetzer, Joel, Kumar, Keshava, Skikne, Barry, MacBeth, Kyle J.
Publié dans PLoS One (2015)

Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome

par Leung, Kevin K., Nguyen, Aaron, Shi, Tao, Tang, Lin, Ni, Xiaochun, Escoubet, Laure, MacBeth, Kyle J., DiMartino, Jorge, Wells, James A.
Publié dans Proc Natl Acad Sci U S A (2019)

A Comparison of Azacitidine and Decitabine Activities in Acute Myeloid Leukemia Cell Lines

par Hollenbach, Paul W., Nguyen, Aaron N., Brady, Helen, Williams, Michelle, Ning, Yuhong, Richard, Normand, Krushel, Leslie, Aukerman, Sharon L., Heise, Carla, MacBeth, Kyle J.
Publié 2010

Phase I Study of Oral Azacitidine in Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, and Acute Myeloid Leukemia

par Garcia-Manero, Guillermo, Gore, Steven D., Cogle, Christopher, Ward, Renee, Shi, Tao, MacBeth, Kyle J., Laille, Eric, Giordano, Heidi, Sakoian, Sarah, Jabbour, Elias, Kantarjian, Hagop, Skikne, Barry
Publié 2011

Impact of somatic mutations on response to lenalidomide in lower-risk non-del(5q) myelodysplastic syndromes patients

par Santini, Valeria, Fenaux, Pierre, Giagounidis, Aristoteles, Platzbecker, Uwe, List, Alan F., Haferlach, Torsten, Zhong, Jim, Wu, Chengqing, Mavrommatis, Konstantinos, Beach, C. L., MacBeth, Kyle J., Almeida, Antonio
Publié dans Leukemia (2020)

Transcriptional Responses to Estrogen and Progesterone in Mammary Gland Identify Networks Regulating p53 Activity

par Lu, Shaolei, Becker, Klaus A., Hagen, Mary J., Yan, Haoheng, Roberts, Amy L., Mathews, Lesley A., Schneider, Sallie S., Siegelmann, Hava T., MacBeth, Kyle J., Tirrell, Stephen M., Blanchard, Jeffrey L., Jerry, D. Joseph
Publié 2008

p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)

par Saft, Leonie, Karimi, Mohsen, Ghaderi, Mehran, Matolcsy, András, Mufti, Ghulam J., Kulasekararaj, Austin, Göhring, Gudrun, Giagounidis, Aristoteles, Selleslag, Dominik, Muus, Petra, Sanz, Guillermo, Mittelman, Moshe, Bowen, David, Porwit, Anna, Fu, Tommy, Backstrom, Jay, Fenaux, Pierre, MacBeth, Kyle J., Hellström-Lindberg, Eva
Publié 2014

Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care

par Döhner, Hartmut, Dolnik, Anna, Tang, Lin, Seymour, John F., Minden, Mark D., Stone, Richard M., del Castillo, Teresa Bernal, Al-Ali, Haifa Kathrin, Santini, Valeria, Vyas, Paresh, Beach, C. L., MacBeth, Kyle J., Skikne, Barry S., Songer, Steve, Tu, Nora, Bullinger, Lars, Dombret, Hervé
Publié dans Leukemia (2018)

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

par Krönke, Jan, Fink, Emma C., Hollenbach, Paul W., MacBeth, Kyle J., Hurst, Slater N., Udeshi, Namrata D., Chamberlain, Philip P., Mani, D.R., Man, Hon Wah, Gandhi, Anita K., Svinkina, Tanya, Schneider, Rebekka K., McConkey, Marie, Järås, Marcus, Griffiths, Elizabeth, Wetzler, Meir, Bullinger, Lars, Cathers, Brian E., Carr, Steven A., Chopra, Rajesh, Ebert, Benjamin L.
Publié dans Nature (2015)

TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype

par Sallman, David A., McLemore, Amy F., Aldrich, Amy L., Komrokji, Rami S., McGraw, Kathy L., Dhawan, Abhishek, Geyer, Susan, Hou, Hsin-An, Eksioglu, Erika A., Sullivan, Amy, Warren, Sarah, MacBeth, Kyle J., Meggendorfer, Manja, Haferlach, Torsten, Boettcher, Steffen, Ebert, Benjamin L., Al Ali, Najla H., Lancet, Jeffrey E., Cleveland, John L., Padron, Eric, List, Alan F.
Publié dans Blood (2020)

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

par Wang, Feng, Morita, Kiyomi, DiNardo, Courtney D., Furudate, Ken, Tanaka, Tomoyuki, Yan, Yuanqing, Patel, Keyur P., MacBeth, Kyle J., Wu, Bin, Liu, Guowen, Frattini, Mark, Matthews, Jairo A., Little, Latasha D., Gumbs, Curtis, Song, Xingzhi, Zhang, Jianhua, Thompson, Erika J., Kadia, Tapan M., Garcia-Manero, Guillermo, Jabbour, Elias, Ravandi, Farhad, Bhalla, Kapil N., Konopleva, Marina, Kantarjian, Hagop M., Andrew Futreal, P., Takahashi, Koichi
Publié dans Nat Commun (2021)

Molecular remission and response patterns in patients with mutant-IDH2 acute myeloid leukemia treated with enasidenib

par Stein, Eytan M., DiNardo, Courtney D., Fathi, Amir T., Pollyea, Daniel A., Stone, Richard M., Altman, Jessica K., Roboz, Gail J., Patel, Manish R., Collins, Robert, Flinn, Ian W., Sekeres, Mikkael A., Stein, Anthony S., Kantarjian, Hagop M., Levine, Ross L., Vyas, Paresh, MacBeth, Kyle J., Tosolini, Alessandra, VanOostendorp, Jason, Xu, Qiang, Gupta, Ira, Lila, Thomas, Risueno, Alberto, Yen, Katharine E., Wu, Bin, Attar, Eyal C., Tallman, Martin S., de Botton, Stéphane
Publié dans Blood (2019)

Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition

par Harding, James J., Lowery, Maeve A., Shih, Alan H., Schvartzman, Juan M., Hou, Shengqi, Famulare, Christopher, Patel, Minal, Roshal, Mikhail, Do, Richard K., Zehir, Ahmet, You, Daoqi, Selcuklu, S. Duygu, Viale, Agnes, Tallman, Martin S., Hyman, David M., Reznik, Ed, Finley, Lydia W.S., Papaemmanuil, Elli, Tosolini, Alessandra, Frattini, Mark G., MacBeth, Kyle J., Liu, Guowen, Fan, Bin, Choe, Sung, Wu, Bin, Janjigian, Yelena Y., Mellinghoff, Ingo K., Diaz, Luis A., Levine, Ross L., Abou-Alfa, Ghassan K., Stein, Eytan M., Intlekofer, Andrew M.
Publié dans Cancer Discov (2018)