Toll-Like Receptors in Chronic Pain

Por Nicotra, Lauren, Loram, Lisa C, Watkins, Linda R, Hutchinson, Mark R
Publicado em 2011

Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1β

Por Lewis, Susannah S., Hutchinson, Mark R., Rezvani, Niloofar, Loram, Lisa C., Zhang, Yingning, Maier, Steven F., Rice, Kenner C., Watkins, Linda R.
Publicado em 2010

Selection, Preparation, and Evaluation of Small-Molecule Inhibitors of Toll-Like Receptor 4

Por Bevan, Douglas E., Martinko, Alexander J., Loram, Lisa C., Stahl, Joshua A., Taylor, Frederick R., Joshee, Sampada, Watkins, Linda R., Yin, Hang
Publicado em 2010

Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation

Por Loram, Lisa C, Taylor, Frederick R, Strand, Keith A, Frank, Matthew G, Sholar, Paige, Harrison, Jacqueline A, Maier, Steven F, Watkins, Linda R
Publicado em 2011

Adenosine 2A receptor agonism: a single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats

Por Loram, Lisa C, Strand, Keith A, Taylor, Frederick R, Sloane, Evan, Van Dam, Anne-Marie, Rieger, Jayson, Maier, Steven F, Watkins, Linda R
Publicado no Brain Behav Immun (2015)

(+)-Naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats

Por Lewis, Susannah S., Loram, Lisa C., Hutchinson, Mark R., Li, Chien-Ming, Zhang, Yingning, Maier, Steven F., Huang, Yong, Rice, Kenner C., Watkins, Linda R.
Publicado em 2012

Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling

Por Loram, Lisa C, Taylor, Frederick R, Strand, Keith A, Harrison, Jacqueline A, RzasaLynn, Rachael, Sholar, Paige, Rieger, Jayson, Maier, Steven F, Watkins, Linda R
Publicado no Brain Behav Immun (2013)

Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy

Por Loram, Lisa C., Grace, Peter M., Strand, Keith A., Taylor, Frederick R., Ellis, Amanda, Berkelhammer, Debra, Bowlin, Melissa, Skarda, Bryce, Maier, Steven F., Watkins, Linda R.
Publicado em 2012

Morphine activates neuroinflammation in a manner parallel to endotoxin

Por Wang, Xiaohui, Loram, Lisa C., Ramos, Khara, de Jesus, Armando J., Thomas, Jacob, Cheng, Kui, Reddy, Anireddy, Somogyi, Andrew A., Hutchinson, Mark R., Watkins, Linda R., Yin, Hang
Publicado em 2012

Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats

Por Loram, Lisa C, Sholar, Paige W., Taylor, Frederick R, Wieseler, Julie, Babb, Jessica A, Strand, Keith A, Berkelhammer, Debra, Day, Heidi EW, Maier, Steven F, Watkins, Linda R
Publicado em 2012

INTRATHECAL INJECTION OF AN ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST ATTENUATES GP120-INDUCED MECHANICAL ALLODYNIA AND SPINAL PRO-INFLAMMATORY CYTOKINE PROFILES IN RATS

Por Loram, Lisa C, Harrison, Jacqueline A, Chao, Lindsey, Taylor, Frederick R, Reddy, Anireddy, Travis, Carissa L, Giffard, Rona, Al-Abed, Yousef, Tracey, Kevin, Maier, Steven F, Watkins, Linda R
Publicado em 2010

Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

Por Hutchinson, Mark R., Northcutt, Alexis L., Chao, Lindsey W., Kearney, Jeffrey J., Zhang, Yingning, Berkelhammer, Debra L., Loram, Lisa C., Rozeske, Robert R., Bland, Sondra T., Maier, Steven F., Gleeson, Todd T., Watkins, Linda R.
Publicado em 2008

Evidence that tricyclic small molecules may possess Toll-like receptor and MD-2 activity

Por Hutchinson, Mark R., Loram, Lisa C., Zhang, Yingning, Shridhar, Mitesh, Rezvani, Niloofar, Berkelhammer, Debra, Phipps, Simon, Foster, Paul S., Landgraf, Kyle, Falke, Joseph J., Rice, Kenner C., Maier, Steven F., Yin, Hang, Watkins, Linda R.
Publicado em 2010

Enduring Reversal of Neuropathic Pain by a Single Intrathecal Injection of Adenosine 2A Receptor Agonists: A Novel Therapy for Neuropathic Pain

Por Loram, Lisa C., Harrison, Jacqueline A., Sloane, Evan M., Hutchinson, Mark R., Sholar, Paige, Taylor, Frederick R., Berkelhammer, Debra, Coats, Benjamen D., Poole, Stephen, Milligan, Erin D., Maier, Steven F., Rieger, Jayson, Watkins, Linda R.
Publicado em 2009

Pain intensity and duration can be enhanced by prior challenge: Initial evidence suggestive of a role of microglial priming

Por Hains, Leah E., Loram, Lisa C., Weiseler, Julie L., Frank, Matthew G., Bloss, Erik B., Sholar, Paige, Taylor, Frederick R, Harrison, Jacqueline A, Martin, Thomas J., Eisenach, James C., Maier, Steven F., Watkins, Linda R.
Publicado em 2010

Evidence for a role of heat shock protein-90 (HSP90) in TLR4 mediated pain enhancement in rats

Por Hutchinson, Mark R., Ramos, Khara M., Loram, Lisa C., Wieseler, Julie, Sholar, Paige W., Kearney, Jeffrey J., Lewis, Makenzie T., Crysdale, Nicole Y., Zhang, Yingning, Harrison, Jacqueline A., Maier, Steven F., Rice, Kenner C., Watkins, Linda R.
Publicado em 2009

Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy

Por Grace, Peter M., Loram, Lisa C., Christianson, John P., Strand, Keith A., Flyer-Adams, Johanna G., Penzkover, Kathryn R., Forsayeth, John R., van Dam, Anne-Marie, Mahoney, Melissa J., Maier, Steven F., Chavez, Raymond A., Watkins, Linda R.
Publicado no Brain Behav Immun (2016)

Release of Plasmid DNA-Encoding IL-10 from PLGA Microparticles Facilitates Long-Term Reversal of Neuropathic Pain Following a Single Intrathecal Administration

Por Soderquist, Ryan Gene, Sloane, Evan M., Loram, Lisa C., Harrison, Jacqueline A., Dengler, Ellen C., Johnson, Scott M., Amer, Luke D., Young, Courtney S., Lewis, Makenzie T., Poole, Stephen, Frank, Matthew G., Watkins, Linda R., Milligan, Erin D., Mahoney, Melissa J.
Publicado em 2010

PRIOR LAPAROTOMY OR CORTICOSTERONE POTENTIATES LIPOPOLYSACCHARIDE-INDUCED FEVER AND SICKNESS BEHAVIORS

Por Hains, Leah E., Loram, Lisa C., Taylor, Frederick R, Strand, Keith A, Wieseler, Julie L., Barrientos, Ruth M., Young, Jennifer J., Frank, Matthew G, Sobesky, Julia, Martin, Thomas J., Eisenach, James C., Maier, Steven F., Johnson, John D., Fleshner, Monika, Watkins, Linda R.
Publicado em 2011