PRIOR LAPAROTOMY OR CORTICOSTERONE POTENTIATES LIPOPOLYSACCHARIDE-INDUCED FEVER AND SICKNESS BEHAVIORS

Stimulating sensitized immune cells with a subsequent immune challenge results in potentiated pro-inflammatory responses translating into exacerbated sickness responses (i.e. fever, pain and lethargy). Both corticosterone (CORT) and laparotomy cause sensitization, leading to enhanced sickness-induce...

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Auteurs principaux: Hains, Leah E., Loram, Lisa C., Taylor, Frederick R, Strand, Keith A, Wieseler, Julie L., Barrientos, Ruth M., Young, Jennifer J., Frank, Matthew G, Sobesky, Julia, Martin, Thomas J., Eisenach, James C., Maier, Steven F., Johnson, John D., Fleshner, Monika, Watkins, Linda R.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205218/
https://ncbi.nlm.nih.gov/pubmed/21907418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2011.08.011
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