(+)-Naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats

Previous work demonstrated that both the opioid antagonist (−)-naloxone and the nonopioid (+)-naloxone inhibit toll-like receptor 4 (TLR4) signaling and reverse neuropathic pain expressed shortly after chronic constriction injury. The present studies reveal that the TLR4 contributes to neuropathic p...

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Detalhes bibliográficos
Main Authors: Lewis, Susannah S., Loram, Lisa C., Hutchinson, Mark R., Li, Chien-Ming, Zhang, Yingning, Maier, Steven F., Huang, Yong, Rice, Kenner C., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348259/
https://ncbi.nlm.nih.gov/pubmed/22520687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2012.02.005
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