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(+)-Naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats
Previous work demonstrated that both the opioid antagonist (−)-naloxone and the nonopioid (+)-naloxone inhibit toll-like receptor 4 (TLR4) signaling and reverse neuropathic pain expressed shortly after chronic constriction injury. The present studies reveal that the TLR4 contributes to neuropathic p...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3348259/ https://ncbi.nlm.nih.gov/pubmed/22520687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2012.02.005 |
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