Selection, Preparation, and Evaluation of Small-Molecule Inhibitors of Toll-Like Receptor 4

[Image: see text] Toll-like receptor 4 (TLR4), a membrane-spanning receptor protein that functions in complex with its accessory protein MD-2, is an intriguing target for therapeutic development. Herein, we report the identification of a series of novel TLR4 inhibitors and the development of a robus...

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Bibliographische Detailangaben
Hauptverfasser: Bevan, Douglas E., Martinko, Alexander J., Loram, Lisa C., Stahl, Joshua A., Taylor, Frederick R., Joshee, Sampada, Watkins, Linda R., Yin, Hang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2010
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930797/
https://ncbi.nlm.nih.gov/pubmed/20824192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100041f
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