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Evidence that tricyclic small molecules may possess Toll-like receptor and MD-2 activity

Opioids have been discovered to have Toll-like receptor (TLR) activity, beyond actions at classical opioid receptors. This raises the question whether other pharmacotherapies for pain control may also possess TLR activity, contributing to or opposing their clinical effects. We document that tricycli...

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Detalhes bibliográficos
Main Authors: Hutchinson, Mark R., Loram, Lisa C., Zhang, Yingning, Shridhar, Mitesh, Rezvani, Niloofar, Berkelhammer, Debra, Phipps, Simon, Foster, Paul S., Landgraf, Kyle, Falke, Joseph J., Rice, Kenner C., Maier, Steven F., Yin, Hang, Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872682/
https://ncbi.nlm.nih.gov/pubmed/20381591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2010.03.067
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