Development of β-Amino Alcohol Derivatives that Inhibit Toll-Like Receptor 4 Mediated Inflammatory Response as Potential Antiseptics

Toll-like Receptor 4 (TLR4) induced pro-inflammatory signaling has been directly implicated in severe sepsis and represents an attractive therapeutic target. Herein, we report our investigations into the structure-activity relationship and preliminary drug metabolism/pharmacokinetics study of β-amin...

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Main Authors: Chavez, Sherry A., Martinko, Alexander J., Lau, Corinna, Pham, Michael N., Cheng, Kui, Bevan, Douglas E., Mollnes, Tom E., Yin, Hang
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131463/
https://ncbi.nlm.nih.gov/pubmed/21591694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2003365
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