Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling

BACKGROUND: Multiple adverse events are associated with the use of morphine for the treatment of chronic non-cancer pain, including opioid-induced hyperalgesia (OIH). Mechanisms of OIH are independent of opioid tolerance and may involve the morphine metabolite morphine-3-glucuronide (M3G). M3G exhib...

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Detalhes bibliográficos
Main Authors: Due, Michael R, Piekarz, Andrew D, Wilson, Natalie, Feldman, Polina, Ripsch, Matthew S, Chavez, Sherry, Yin, Hang, Khanna, Rajesh, White, Fletcher A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519737/
https://ncbi.nlm.nih.gov/pubmed/22898544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-200
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