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Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy
Opioids, such as morphine, induce potent analgesia and are the gold standard for the treatment of acute pain. However, opioids also activate glia, inducing pro-inflammatory cytokine and chemokine production, which counter-regulates the analgesic properties of classical opioid receptor activation. It...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491069/ https://ncbi.nlm.nih.gov/pubmed/22902523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2012.08.003 |
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