Repeated Morphine Prolongs Postoperative Pain in Male Rats

BACKGROUND: Opioids are effective postoperative analgesics. Disturbingly, we have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain. These deleterious effects are mediated by immune mediators that promote neuronal hyperexcitabi...

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Библиографические подробности
Опубликовано в: :Anesth Analg
Главные авторы: Grace, Peter M., Galer, Erika L., Strand, Keith A., Corrigan, Kaci, Berkelhammer, Debra, Maier, Steven F., Watkins, Linda R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054903/
https://ncbi.nlm.nih.gov/pubmed/29596097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000003345
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