DREADDed microglia in pain: implications for spinal inflammatory signaling in male rats

The absence of selective pharmacological tools is a major barrier to the in vivo study of microglia. To address this issue, we developed a G(q)- and G(i)-coupled Designer Receptor Exclusively Activated by a Designer Drug (DREADD) to enable selective stimulation or inhibition of microglia, respective...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Grace, Peter M., Wang, Xiaohui, Strand, Keith A., Baratta, Michael V., Zhang, Yingning, Galer, Erika L., Yin, Hang, Maier, Steven F., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916033/
https://ncbi.nlm.nih.gov/pubmed/29530713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2018.03.005
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