Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

Opioid use for pain management has dramatically increased, with little assessment of potential pathophysiological consequences for the primary pain condition. Here, a short course of morphine, starting 10 d after injury in male rats, paradoxically and remarkably doubled the duration of chronic const...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Grace, Peter M., Strand, Keith A., Galer, Erika L., Urban, Daniel J., Wang, Xiaohui, Baratta, Michael V., Fabisiak, Timothy J., Anderson, Nathan D., Cheng, Kejun, Greene, Lisa I., Berkelhammer, Debra, Zhang, Yingning, Ellis, Amanda L., Yin, Hang Hubert, Campeau, Serge, Rice, Kenner C., Roth, Bryan L., Maier, Steven F., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914184/
https://ncbi.nlm.nih.gov/pubmed/27247388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602070113
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