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Repeated Morphine Prolongs Postoperative Pain in Male Rats

BACKGROUND: Opioids are effective postoperative analgesics. Disturbingly, we have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain. These deleterious effects are mediated by immune mediators that promote neuronal hyperexcitabi...

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Detalhes bibliográficos
Publicado no:Anesth Analg
Main Authors: Grace, Peter M., Galer, Erika L., Strand, Keith A., Corrigan, Kaci, Berkelhammer, Debra, Maier, Steven F., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054903/
https://ncbi.nlm.nih.gov/pubmed/29596097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000003345
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