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Repeated Morphine Prolongs Postoperative Pain in Male Rats

BACKGROUND: Opioids are effective postoperative analgesics. Disturbingly, we have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain. These deleterious effects are mediated by immune mediators that promote neuronal hyperexcitabi...

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Bibliografiske detaljer
Udgivet i:Anesth Analg
Main Authors: Grace, Peter M., Galer, Erika L., Strand, Keith A., Corrigan, Kaci, Berkelhammer, Debra, Maier, Steven F., Watkins, Linda R.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054903/
https://ncbi.nlm.nih.gov/pubmed/29596097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000003345
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