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Repeated Morphine Prolongs Postoperative Pain in Male Rats

BACKGROUND: Opioids are effective postoperative analgesics. Disturbingly, we have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain. These deleterious effects are mediated by immune mediators that promote neuronal hyperexcitabi...

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Podrobná bibliografie
Vydáno v:Anesth Analg
Hlavní autoři: Grace, Peter M., Galer, Erika L., Strand, Keith A., Corrigan, Kaci, Berkelhammer, Debra, Maier, Steven F., Watkins, Linda R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054903/
https://ncbi.nlm.nih.gov/pubmed/29596097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000003345
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