Atomic resolution structures of Escherichia coli and Bacillus anthracis malate synthase A: Comparison with isoform G and implications for structure-based drug discovery

Por Lohman, Jeremy R., Olson, Andrew C., Remington, S. James
Publicado em 2008

Utilizing the GAAA tetraloop/receptor to facilitate crystal packing and structure determination of a CUG RNA helix

Por Coonrod, Leslie A., Lohman, Jeremy R., Berglund, J. Andrew
Publicado em 2012

C-S bond cleavage by a polyketide synthase domain

Por Ma, Ming, Lohman, Jeremy R., Liu, Tao, Shen, Ben
Publicado no Proc Natl Acad Sci U S A (2015)

A new member of the 4-methylideneimidazole-5-one–containing aminomutase family from the enediyne kedarcidin biosynthetic pathway

Por Huang, Sheng-Xiong, Lohman, Jeremy R., Huang, Tingting, Shen, Ben
Publicado em 2013

The Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double Hot Dog Fold

Por Lohman, Jeremy R., Bingman, Craig A., Phillips, George N., Shen, Ben
Publicado em 2013

The Post-polyketide Synthase Steps in iso-Migrastatin Biosynthesis Featuring Tailoring Enzymes with Broad Substrate Specificity

Por Ma, Ming, Kwong, Thomas, Lim, Si-Kyu, Ju, Jianhua, Lohman, Jeremy R., Shen, Ben
Publicado em 2013

Enediyne Polyketide Synthases Stereoselectively Reduce the β-Ketoacyl Intermediates to β-d-Hydroxyacyl Intermediates in Enediyne Core Biosynthesis

Por Ge, Hui-Ming, Huang, Tingting, Rudolf, Jeffrey D., Lohman, Jeremy R., Huang, Sheng-Xiong, Guo, Xun, Shen, Ben
Publicado em 2014

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads

Por Shen, Ben, Hindra, Yan, Xiaohui, Huang, Tingting, Ge, Huiming, Yang, Dong, Teng, Qihui, Rudolf, Jeffrey D., Lohman, Jeremy R.
Publicado no Bioorg Med Chem Lett (2014)

Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10)

Por Park, HaJeung, González, Àlex L., Yildirim, Ilyas, Tran, Tuan, Lohman, Jeremy R., Fang, Pengfei, Guo, Min, Disney, Matthew D.
Publicado no Biochemistry (2015)

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitum...

Por Lohman, Jeremy R., Huang, Sheng-Xiong, Horsman, Geoffrey P., Dilfer, Paul E., Huang, Tingting, Chen, Yihua, Wendt-Pienkowski, Evelyn, Shen, Ben
Publicado em 2013

The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins

Por Lohman, Jeremy R., Ma, Ming, Cuff, Marianne E., Bigelow, Lance, Bearden, Jessica, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado em 2014

Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

Por Yin, Min, Yan, Yijun, Lohman, Jeremy R., Huang, Sheng-Xiong, Ma, Ming, Zhao, Guang-Rong, Xu, Li-Hua, Xiang, Wensheng, Shen, Ben
Publicado em 2014

Structure of the Myotonic Dystrophy Type 2 RNA and Designed Small Molecules That Reduce Toxicity

Por Childs-Disney, Jessica L., Yildirim, Ilyas, Park, HaJeung, Lohman, Jeremy R., Guan, Lirui, Tran, Tuan, Sarkar, Partha, Schatz, George C., Disney, Matthew D.
Publicado em 2013

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

Por Annaval, Thibault, Rudolf, Jeffrey D., Chang, Chin-Yuan, Lohman, Jeremy R., Kim, Youngchang, Bigelow, Lance, Jedrzejczak, Robert, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado no ACS Omega (2017)

Comparative Characterization of the Lactimidomycin and iso-Migrastatin Biosynthetic Machineries Revealing Unusual Features for Acyltransferase-less Type I Polyketide Synthases and...

Por Seo, Jeong-Woo, Ma, Ming, Kwong, Thomas, Ju, Jianhua, Lim, Si-Kyu, Jiang, Hui, Lohman, Jeremy R., Yang, Chunying, Cleveland, John, Zazopoulos, Emmanuel, Farnet, Chris M., Shen, Ben
Publicado no Biochemistry (2014)

Strain Prioritization for Natural Product Discovery by a High-Throughput Real-Time PCR Method

Por Hindra, Huang, Tingting, Yang, Dong, Rudolf, Jeffrey D., Xie, Pengfei, Xie, Guangbo, Teng, Qihui, Lohman, Jeremy R., Zhu, Xiangcheng, Huang, Yong, Zhao, Li-Xing, Jiang, Yi, Duan, Yanwen, Shen, Ben
Publicado em 2014

Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892

Por Rudolf, Jeffrey D., Bigelow, Lance, Chang, Changsoo, Cuff, Marianne E., Lohman, Jeremy R., Chang, Chin-Yuan, Ma, Ming, Yang, Dong, Clancy, Shonda, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado no Biochemistry (2015)

Structural and evolutionary relationships of “AT-less” type I polyketide synthase ketosynthases

Por Lohman, Jeremy R., Ma, Ming, Osipiuk, Jerzy, Nocek, Boguslaw, Kim, Youngchang, Chang, Changsoo, Cuff, Marianne, Mack, Jamey, Bigelow, Lance, Li, Hui, Endres, Michael, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado no Proc Natl Acad Sci U S A (2015)

Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species

Por Huang, Sheng-Xiong, Yun, Bong-Sik, Ma, Ming, Basu, Hirak S., Church, Dawn R., Ingenhorst, Gudrun, Huang, Yong, Yang, Dong, Lohman, Jeremy R., Tang, Gong-Li, Ju, Jianhua, Liu, Tao, Wilding, George, Shen, Ben
Publicado no Proc Natl Acad Sci U S A (2015)

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne A...

Por Chang, Chin-Yuan, Lohman, Jeremy R., Cao, Hongnan, Tan, Kemin, Rudolf, Jeffrey D., Ma, Ming, Xu, Weijun, Bingman, Craig A., Yennamalli, Ragothaman M., Bigelow, Lance, Babnigg, Gyorgy, Yan, Xiaohui, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Publicado no Biochemistry (2016)